Sinclair Method Studies
This article examines the scientific foundation behind TSM, drawing on nearly three decades of peer‑reviewed trials, neuroimaging research, and systematic reviews.
Alcohol and Society | Stigma, Science, and the Truth We Avoid
Society has a complicated relationship with alcohol. It’s celebrated, normalised; woven into nearly every occasion: births, business meetings, dates, parties. Yet when someone develops a problem with the same substance - reaction changes completely.
Gradual Reduction with The Sinclair Method: Why It Works
That’s where The Sinclair Method (TSM) shines. This innovative approach offers an alternative: gradual reduction, using the medication naltrexone to change your brain’s response to alcohol, one drink at a time.
Rethink Drink – Leading Providers of the Sinclair Method in the UK
At Rethink Drink, we're proud to be leading the charge in reshaping how the UK approaches alcohol recovery. For too long, individuals seeking change have faced limited choices: abstinence-only programmes, rigid systems, and shame-based narratives. We exist to offer a smarter, science-backed alternative — The Sinclair Method (TSM).
Does The Sinclair Method Work? Exploring Its Success and Science
The Sinclair Method (TSM) is a medication-based treatment for Alcohol Use Disorder (AUD) that allows individuals to continue drinking while retraining their brain’s response to alcohol. The cornerstone of this method is naltrexone, an opioid blocker that dulls the endorphin rush typically triggered by alcohol.
The Science of Addiction: Understanding Endorphins and Their Role in Alcohol Use
Understanding the science of addiction is crucial for anyone on the path to recovery or supporting a loved one through it. At the core of addiction lies a powerful biochemical mechanism driven by the brain’s natural reward system—most notably, endorphins. These feel-good chemicals play a pivotal role in reinforcing behaviours, and when substances like alcohol exploit this system, the result can be a cycle that’s difficult to break.
Trustpilot Reviews Supporting Rethink Drink’s Sinclair Method Journey
Rethink Drink’s Trustpilot page features many verified reviews from clients who’ve experienced life-changing results. Ranging from liberation from daily drinking to newfound confidence, the feedback reflects genuine transformation through the Sinclair Method.
The Sunday Reset
Every Sunday, we share a 2-minute insight into the logic of the Sinclair Method.
Join thousands of others for our weekly newsletter and change how you see the problem,
because when you change the way you look at things, the things you look at change.
… There’s a reason we’re called Rethink Drink!
