Sinclair Method Studies
This article examines the scientific foundation behind TSM, drawing on nearly three decades of peer‑reviewed trials, neuroimaging research, and systematic reviews.
Founded by Matt Brindley and Bruce Rose, Rethink Drink champions an evidence-based, client-centred approach known as The Sinclair Method (TSM). They’re not just another recovery service—they’re redefining what it means to take back control.
Sleep isn't a flatline—it's a structured sequence of stages. Each night, we move through several sleep cycles, each lasting roughly 90–120 minutes. These cycles are made up of NREM (Non-Rapid Eye Movement) and REM (Rapid Eye Movement) phases
The Sinclair Method is a treatment approach for Alcohol Use Disorder (AUD) that involves taking the medication naltrexone before consuming alcohol. Unlike traditional abstinence-based treatments, TSM allows individuals to continue drinking while the medication works to reduce cravings over time. This process, known as pharmacological extinction, helps individuals regain control over their drinking habits.
While naltrexone is the key medical component, TSM is not just about taking a pill. Success relies on consistent use, tracking progress, and having the right support system in place. That’s why professional guidance is essential—it helps users navigate challenges and build sustainable habits.